Operating at the leading-edge phenotypic screening, we are committed to sharing up-to-date and accurate information with our partners.
CE Bioscience Limited is also actively engaged in cutting-edge basic research.
Human health
A cys-loop mutation in the C. elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function
Jones, A.K., Rayes, D., Jones, R., Maynard, T., Al-Diwani, A. Matthews, S., Bouzat, C. and Sattelle, D.B. (2011)
A model for congenital myasthenia syndrome validated by drugs in current clinical use
C. elegans models of neuromuscular disorders expedite translational research
Sleigh J.N. and Sattelle, D.B. (2010)
Neuromuscular disease models and screening potential reviewed
Alzheimer’s disease and other neurodegenerative diseases: insights from Drosophila melanogaster genetic models
Moloney, A.M., Sattelle, D.B., Lomas, D.A. and Crowther, D.C. (2010)
Alzheimer’s disease models
Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons
Jones, A.K., Buckingham, S.D. and Sattelle, D.B. (2010)
Searching for new drug tragets
Animal health
Actions of agonists, Fipronil and Ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytes
Lees K., Musgaard M., Suwanmanee S., Buckingham S.D., Biggin P. and Sattelle DB.
Finding the correct target to aim at in Animal Health Drug Discovery
Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to Ivermectin-resistant C. elegans
Glendinning, S.K., Buckingham, S.D., Sattelle, D.B., Wonnacott, S. and Wolstenholme, A.J.
Transgenics facilitating studies on parasite drug targets
Ligand Gated Ion Channels as Targets for Anthelmintic Drugs: Past, Current and Future Perspectives.
In Antiparasitic and Antibacterial Drug Discovery: from Molecular Targets to Drug Candidates
Lees, K., Sluder, A., Shannan, N., Hammerland, L. and Sattelle, D.B. (2011)
(ed Conor Caffrey) pp 3-21.Wiley – VCH Verlag GmbH & Co. KGaA.
Antiparasitic drug targets
Crop protection
Identification of ion channel genes in the Pea Aphid Genome
Dale RP, Jones AK, Tamborindeguy C, Davies TG, Amey JS, Williamson S, Wolstenholme A, Field LM, Williamson MS, Walsh TK, Sattelle DB. (2010)
Insect Molecular Biology 19, 141-153
Crop pest control target understanding enhanced by genomics
Insights from Three Genomes of Nasonia: Insect Natural Enemies and Emerging Genetic Model
The Nasonia Genome Consortium (incl Jones, A.K., Bera, A., Lees, K. and Sattelle, D.B.) (2010)
Biological control understanding enhanced by genomics