Publications

Operating at the leading-edge phenotypic screening, we are committed to sharing up-to-date and accurate information with our partners.

CE Bioscience Limited is also actively engaged in cutting-edge basic research.

 

Human health

 

A cys-loop mutation in the C. elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function

Jones, A.K., Rayes, D., Jones, R., Maynard, T., Al-Diwani, A. Matthews, S., Bouzat, C. and Sattelle, D.B. (2011) 

J. Biol. Chem.  286, 2550-2558

A model for congenital myasthenia syndrome validated by drugs in current clinical use

 

C. elegans models of neuromuscular disorders expedite translational research

Sleigh J.N. and Sattelle, D.B. (2010)

Transl Neurosci 1, 214-227

Neuromuscular disease models and screening potential reviewed

 

Alzheimer’s disease and other neurodegenerative diseases: insights from Drosophila melanogaster genetic models

Moloney, A.M., Sattelle, D.B., Lomas, D.A. and Crowther, D.C. (2010)

TIBS 35, 228-235

Alzheimer’s disease models

 

Proteins interacting with nicotinic acetylcholine receptors: expanding functional and therapeutic horizons

Jones, A.K., Buckingham, S.D. and Sattelle, D.B. (2010)

TIPS 2010 31, 455-62

Searching for new drug tragets

 

 

Animal health

 

Actions of agonists, Fipronil and Ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytes

Lees K., Musgaard M., Suwanmanee S., Buckingham S.D., Biggin P. and Sattelle DB.

PLoS One 9(5): e97468

Finding the correct target to aim at in Animal Health Drug Discovery

 

Glutamate-gated chloride channels of Haemonchus contortus restore drug sensitivity to Ivermectin-resistant C. elegans

Glendinning, S.K., Buckingham, S.D., Sattelle, D.B., Wonnacott, S. and Wolstenholme, A.J.

PLoS One 6:e22390

Transgenics facilitating studies on parasite drug targets

 

Ligand Gated Ion Channels as Targets for Anthelmintic Drugs: Past, Current and Future Perspectives.

In Antiparasitic and Antibacterial Drug Discovery: from Molecular Targets to Drug Candidates 

Lees, K., Sluder, A., Shannan, N., Hammerland, L. and Sattelle, D.B. (2011)

(ed Conor Caffrey) pp 3-21.Wiley – VCH Verlag GmbH & Co. KGaA.

Antiparasitic drug targets

 

 

Crop protection

 

Identification of ion channel genes in the Pea Aphid Genome

Dale RP, Jones AK, Tamborindeguy C, Davies TG, Amey JS, Williamson S, Wolstenholme A, Field LM, Williamson MS, Walsh TK, Sattelle DB. (2010)

Insect Molecular Biology 19, 141-153

Crop pest control target understanding enhanced by genomics

 

Insights from Three Genomes of Nasonia: Insect Natural Enemies and Emerging Genetic Model

The Nasonia Genome Consortium (incl Jones, A.K., Bera, A., Lees, K. and Sattelle, D.B.) (2010)

Science 327, 343-348

Biological control understanding enhanced by genomics